Hair loss can seriously knock your confidence, especially if it starts early. I’ve dealt with it for years and tested just about every option available. Lately, I’ve been seeing real results using a premixed solution that combines RU58841 with 5% Minoxidil.
This combo is easy to apply, targets the root causes of hair loss, and avoids the hormonal side effects often linked to Finasteride & Dutasteride (oral & topical 5a-reductase inhibitors).
In this post, I’ll explain how it works, what the research says, what side effects to consider, and how it’s working for me so far.
What Is RU58841 and Why Use It With Minoxidil?
RU58841 is a topical anti-androgen. It helps by stopping DHT from binding to receptors in your scalp. DHT is the hormone responsible for shrinking hair follicles and causing male pattern baldness.
Minoxidil works differently. It increases blood flow to the follicles, encourages growth, and supports a longer hair cycle.
Using both gives you two levels of support:
- RU58841 blocks DHT at the scalp, preventing follicle minaturisation
- Minoxidil boosts regrowth by improving follicle activity & bloodflow
Together, they form a solid foundation for preventing loss and encouraging new growth.
Why I Chose the Premixed Formula
The premix I am using contains 50 mg of RU58841 and 5% Minoxidil per ml. I chose it for a few reasons:
- It saves time with a single daily application
- The dose is pre-measured, so I know exactly what I’m using
- The formula dries quickly and doesn’t leave residue
- No mixing, no fuss
I apply one ml every night, using a spray bottle addressing my entire scalp.
How RU58841 Works
DHT is the main driver behind male pattern baldness. It binds to androgen receptors in your scalp, causing follicles to shrink over time.
RU58841 binds to those same receptors before DHT can, helping prevent the damage. Since it’s applied topically, it works directly on the scalp and doesn’t affect DHT levels elsewhere in the body. This local action makes it an appealing option for people who want to avoid the risks of systemic hormone blockers (finasteride & dutasteride).
What the Research Says
RU58841 is still considered experimental, but early studies and user experiences look promising.
Animal Studies:
- RU58841 helped maintain hair growth in rodents exposed to high levels of DHT
- In some cases, it showed better follicle preservation than Finasteride
Human Anecdotes:
- Many users report slowed hair loss and some regrowth
- Often used by those who can’t tolerate Finasteride
- Results typically appear after three to six months of consistent use
Anecdotal doesn’t mean guaranteed, but it does suggest real-world potential.
Side Effects and Considerations
So far, I haven’t noticed any major side effects. But thats not to say there isnt any, here’s what you might expect:
Possible mild effects:
- Scalp dryness or itchiness
- Temporary shedding in the first few weeks/months
Less common:
- Skin irritation depending on the carrier used
- Very low chance of systemic absorption when applied correctly
For best results, make sure the product is stored properly, preferably in a cool, dark place like a fridge, and only apply to clean, dry skin.
My Routine and Experience So Far
- One ml of the premixed solution daily (pm), applied across my entire scalp
- Supporting routine includes ketoconazole shampoo a few times a week
- Microneedling once weekly with a 1.5 mm dermastamp
Results so far:
- First two months: excessive shedding
- By month three: lessened shedding & visible thickening at the temples
- By month four: maintaining what I have, much less hairfall
Should You Try It?
This solution is ideal for anyone who:
- Wants to avoid oral DHT blockers
- Is already using Minoxidil but not seeing enough progress
- Is looking for a topical stack with both maintenance and regrowth potential
It won’t reverse baldness overnight, but it gives you a strong chance at keeping what you’ve got and maybe even regaining some ground.
FAQs
Is RU58841 legal?
It’s legal to buy for research purposes in many countries but isn’t approved by the FDA for hair loss treatment.
Can I use it at morning instead of the night?
Yes, timing doesn’t matter as long as the scalp is clean and the product dries fully.
Do I need to use microneedling or shampoo too?
They can help but aren’t essential. The core of this protocol is the RU58841 and Minoxidil combo. RU to compete with DHT on the scalp & minoxidil to increase bloodflow.
Want My Full Hair Loss Protocol?
I’ve put together everything I’ve learned into a free downloadable guide. It covers products, supplements, and tracking tips.
